[Effect of phenibut on interhemispheric transmission in the rat brain]

Eksp Klin Farmakol. Jan-Feb 2009;72(1):57-9.
[Article in Russian]

Abstract

Effects of the nootropic drug phenibut on the transcallosal potential amplitude in the sensomotor brain cortex have been studied in rats. It is established that a single administration of phenibut in a dose of 25 mg/kg (i.p.) increases the transcallosal response amplitude, thus improving the interhemispheric transmission. This effect, being an objective evidence of the nootrope activity, confirms the drug status and corroborates the positive action of phenibut on the learning and memory processes.

MeSH terms

  • Animals
  • Cerebral Cortex / drug effects*
  • Cerebral Cortex / physiology
  • Evoked Potentials, Somatosensory / drug effects
  • Evoked Potentials, Somatosensory / physiology
  • Male
  • Nootropic Agents / pharmacology*
  • Rats
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • gamma-Aminobutyric Acid / analogs & derivatives*
  • gamma-Aminobutyric Acid / pharmacology

Substances

  • Nootropic Agents
  • gamma-Aminobutyric Acid
  • 4-amino-3-phenylbutyric acid