Serum vascular adhesion protein-1 is increased in acute and chronic hyperglycemia

Clin Chim Acta. 2009 Jun 27;404(2):149-53. doi: 10.1016/j.cca.2009.03.041. Epub 2009 Mar 29.

Abstract

Background: The relationship between serum vascular adhesion protein-1 (VAP-1) and plasma glucose in normal and drug-naïve type 2 diabetes subjects is unclear. We examined if serum VAP-1 changed acutely to oral glucose loading and analyzed the relationship between serum VAP-1, fasting plasma glucose (FPG), hemoglobin A1c, and type 2 diabetes.

Methods: Adults without history of diabetes were included. Subjects taking anti-diabetic drugs were excluded. Serum VAP-1 was analyzed by time-resolved immunofluorometric assay.

Results: We recruited 333 subjects (186 females and 147 males), aged 56.1 +/- 11.6 y. After glucose challenge, serum VAP-1 rose significantly at 30 min (p < 0.0001) and lasted until 2 h (p < 0.0001). The change of serum VAP-1 between fasting and 30-min postload correlated inversely to the change of plasma insulin (r = -0.21, p = 0.049). Fasting serum VAP-1 was associated with FPG in those with FPG > or = 5.55 mmol/l (p = 0.025) but not in those with FPG < 5.55 mmol/l (p = NS). Fasting serum VAP-1 were higher in diabetic subjects (p = 0.04) and correlated positively to hemoglobin A1c (r = 0.18, p = 0.002) after adjusting for age, gender, and waist circumference.

Conclusions: Serum VAP-1 is increased in both acute and chronic hyperglycemia. Whether serum VAP-1 is a good biomarker for hyperglycemia-associated complications merits further investigation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Disease
  • Aged
  • Amine Oxidase (Copper-Containing) / blood*
  • Biomarkers / blood
  • Blood Glucose / analysis
  • Cell Adhesion Molecules / blood*
  • Chronic Disease
  • Diabetes Mellitus, Type 2 / complications*
  • Fasting / blood
  • Female
  • Glucose / administration & dosage
  • Glycated Hemoglobin A / analysis
  • Humans
  • Hyperglycemia / blood*
  • Hyperglycemia / etiology
  • Male
  • Middle Aged

Substances

  • Biomarkers
  • Blood Glucose
  • Cell Adhesion Molecules
  • Glycated Hemoglobin A
  • hemoglobin A1c protein, human
  • AOC3 protein, human
  • Amine Oxidase (Copper-Containing)
  • Glucose