Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus

Diabetes. 2009 Apr;58(4):773-95. doi: 10.2337/db09-9028.

Author

Ralph A Defronzo¹

Affiliation

¹ Diabetes Division, University of Texas Health Science Center, San Antonio, Texas, USA. albarado@uthscsa.edu

No abstract available

Publication types

Lecture

MeSH terms

Adipose Tissue / pathology
Adipose Tissue / physiopathology
Amyloid / metabolism
Diabetes Mellitus, Type 2 / physiopathology*
Diabetes Mellitus, Type 2 / therapy
Glucose / physiology
Humans
Insulin / metabolism
Insulin Resistance / physiology
Insulin Secretion
Insulin-Secreting Cells / pathology
Insulin-Secreting Cells / physiology*
Islet Amyloid Polypeptide
Liver / physiopathology
Muscle, Skeletal / physiopathology
Obesity / physiopathology
Prediabetic State / physiopathology

Substances

Amyloid
Insulin
Islet Amyloid Polypeptide
Glucose