Therapy-related myeloid neoplasms

Haematologica. 2009 Apr;94(4):454-9. doi: 10.3324/haematol.2008.005157.


Therapy-related myeloid neoplasm is the term recently proposed by the World Health Organization to cover the spectrum of malignant disorders previously described as therapy-related myelodysplastic syndrome or therapy-related acute myeloid leukemia. In this perspective article, Dr. Larson explores the important question of whether the poor prognosis of these conditions reflects t-MN per se or, rather, associated findings such as complex cytogenetics that are also seen, although less frequently, in de novo myeloid neoplasms. See related article on page 542.

Publication types

  • Comment
  • Review

MeSH terms

  • Alkylating Agents / adverse effects
  • Combined Modality Therapy
  • Disease Management
  • Humans
  • Myeloproliferative Disorders / etiology
  • Myeloproliferative Disorders / genetics
  • Myeloproliferative Disorders / therapy*
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / genetics
  • Neoplasms, Second Primary / therapy*
  • Radiotherapy / adverse effects


  • Alkylating Agents