5 alpha-reductase and aromatase inhibitory constituents from Brassica rapa L. pollen

Chem Pharm Bull (Tokyo). 2009 Apr;57(4):401-4. doi: 10.1248/cpb.57.401.

Abstract

In the screening of biologically active constituents from Brassica rapa pollen, the supercritical CO(2) fluid extract (SFE-CO(2)) showed potent 5 alpha-reductase and aromatase inhibiting activity. The SFE-CO(2) extract was separated by various chromatographic methods to give two new phytosterol derivatives, 24-methylenecholesterol linolenate (1) and cycloeucalenol linolenate (2), as well as eight known compounds, 24-methylenecholesterol palmitate (3), cycloeucalenol (4), pollinastanol (5), 24-methylenecholesterol (6), linolenic acid (7), palmitic acid (8), monolinolein (9) and monopalmitin (10), compounds 7 and 9 showed potent 5 alpha-reductase inhibitory activity; compounds 1-6 and 10 showed potent aromatase inhibitory activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-alpha Reductase Inhibitors*
  • Aromatase / metabolism*
  • Aromatase Inhibitors / isolation & purification
  • Aromatase Inhibitors / pharmacology
  • Brassica rapa / chemistry*
  • Enzyme Inhibitors / isolation & purification
  • Enzyme Inhibitors / pharmacology*
  • Molecular Structure
  • Pollen / chemistry

Substances

  • 5-alpha Reductase Inhibitors
  • Aromatase Inhibitors
  • Enzyme Inhibitors
  • Aromatase