Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes

Nat Rev Drug Discov. 2009 Apr;8(4):308-20. doi: 10.1038/nrd2830.

Abstract

Thyroid hormones influence heart rate, serum lipids, metabolic rate, body weight and multiple aspects of lipid, carbohydrate, protein and mineral metabolism. Although increased thyroid hormone levels can improve serum lipid profiles and reduce fat, these positive effects are counterbalanced by harmful effects on the heart, muscle and bone. Thus, attempts to use thyroid hormones for cholesterol-lowering and weight loss purposes have so far been limited. However, over the past decade, thyroid hormone analogues that are capable of uncoupling beneficial effects from deleterious effects have been developed. Such drugs could serve as powerful new tools to address two of the largest medical problems in developed countries--atherosclerosis and obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Obesity Agents / chemical synthesis*
  • Anti-Obesity Agents / therapeutic use
  • Atherosclerosis / drug therapy*
  • Atherosclerosis / metabolism
  • Diabetes Mellitus, Type 2 / drug therapy*
  • Diabetes Mellitus, Type 2 / metabolism
  • Humans
  • Molecular Mimicry*
  • Obesity / drug therapy*
  • Obesity / metabolism
  • Thyroid Hormones / chemical synthesis*
  • Thyroid Hormones / metabolism
  • Thyroid Hormones / therapeutic use*

Substances

  • Anti-Obesity Agents
  • Thyroid Hormones