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. 2008 Dec;4(6):1343-58.
doi: 10.2147/tcrm.s4328.

Effects of Treatment With Antimicrobial Agents on the Human Colonic Microflora

Free PMC article

Effects of Treatment With Antimicrobial Agents on the Human Colonic Microflora

Fatemeh Rafii et al. Ther Clin Risk Manag. .
Free PMC article


Antimicrobial agents are the most valuable means available for treating bacterial infections. However, the administration of therapeutic doses of antimicrobial agents to patients is a leading cause of disturbance of the normal gastrointestinal microflora. This disturbance results in diminishing the natural defense mechanisms provided by the colonic microbial ecosystem, making the host vulnerable to infection by commensal microorganisms or nosocomial pathogens. In this minireview, the impacts of antimicrobials, individually and in combinations, on the human colonic microflora are discussed.

Keywords: antibiotics; intestinal bacteria.

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    1. Adamsson I, Edlund C, Sjostedt S, et al. Comparative effects of cefadroxil and phenoxymethylpenicillin on the normal oropharyngeal and intestinal microflora. Infection. 1997;25:154–8. - PubMed
    1. Adamsson I, Nord CE, Lundquist P, et al. Comparative effects of omeprazole, amoxycillin plus metronidazole versus omeprazole, clarithromycin plus metronidazole on the oral, gastric and intestinal microflora in Helicobacter pylori-infected patients. J Antimicrob Chemother. 1999;44:629–40. - PubMed
    1. Al-Nassir WN, Sethi AK, Li Y, et al. Both oral metronidazole and oral vancomycin promote persistent overgrowth of vancomycin-resistant enterococci during treatment of Clostridium difficile-associated disease. Antimicrob Agents Chemother. 2008;52:2403–6. - PMC - PubMed
    1. Aldridge KE, Ashcraft D, Cambre K, et al. Multicenter survey of the changing in vitro antimicrobial susceptibilities of clinical isolates of Bacteroides fragilis group, Prevotella, Fusobacterium, Porphyromonas, and Peptostreptococcus species. Antimicrob Agents Chemother. 2001;45:1238–43. - PMC - PubMed
    1. Alestig K, Carlberg H, Nord CE, et al. Effect of cefoperazone on faecal flora. J Antimicrob Chemother. 1983;12:163–7. - PubMed

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