Vascular consequences of dietary salt intake

Am J Physiol Renal Physiol. 2009 Aug;297(2):F237-43. doi: 10.1152/ajprenal.00027.2009. Epub 2009 Apr 1.


Animal and human studies support an untoward effect of excess dietary NaCl (salt) intake on cardiovascular and renal function and life span. Recent work has promoted the concept that the endothelium, in particular, reacts to changes in dietary salt intake through a complex series of events that are independent of blood pressure and the renin-angiotensin-aldosterone axis. The cellular signaling events culminate in the intravascular production of transforming growth factor-beta (TGF-beta) and nitric oxide in response to increased salt intake. Plasticity of the endothelium is integral in the vascular remodeling consequences associated with excess salt intake, because nitric oxide serves as a negative regulator of TGF-beta production. Impairment of nitric oxide production, such as occurs with endothelial dysfunction in a variety of disease states, results in unopposed excess vascular TGF-beta production, which promotes reduced vascular compliance and augmented peripheral arterial constriction and hypertension. Persistent alterations in vascular function promote the increase in cardiovascular events and reductions in renal function that reduce life span during increased salt intake.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / etiology*
  • Cardiovascular Diseases / metabolism
  • Cardiovascular Diseases / physiopathology
  • Endothelium, Vascular / drug effects*
  • Endothelium, Vascular / metabolism
  • Endothelium, Vascular / physiopathology
  • Hemodynamics / drug effects
  • Humans
  • Kidney / drug effects
  • Longevity / drug effects
  • Nitric Oxide / metabolism
  • Signal Transduction / drug effects
  • Sodium Chloride, Dietary / adverse effects*
  • Transforming Growth Factor beta1 / metabolism
  • Up-Regulation


  • Sodium Chloride, Dietary
  • Transforming Growth Factor beta1
  • Nitric Oxide