A randomized, double-blind, placebo-controlled trial of naltrexone in the treatment of concurrent alcohol use disorder and pathological gambling

Am J Addict. 2009 May-Jun;18(3):219-25. doi: 10.1080/10550490902787007.


The efficacy of naltrexone as a treatment for concurrent alcohol abuse or dependence and pathological gambling was evaluated in a randomized, double-blind, placebo-controlled trial. Fifty-two, mostly male, subjects were recruited from the community and received 11 weeks of medication during which cognitive-behavioral counseling was also provided. No significant group differences were found on any alcohol or gambling variable (ie, frequency, quantity, expenditures) at post-treatment or at the one year follow-up. However, a strong time effect was found suggesting that treatment, in general, was effective. The use of naltrexone to treat concurrent alcohol use and gambling problems was not supported.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcohol Drinking / prevention & control
  • Alcoholism / complications
  • Alcoholism / drug therapy*
  • Cognitive Behavioral Therapy
  • Double-Blind Method
  • Female
  • Follow-Up Studies
  • Gambling* / psychology
  • Humans
  • Male
  • Medication Adherence
  • Naltrexone / adverse effects
  • Naltrexone / therapeutic use*
  • Placebos
  • Time Factors


  • Placebos
  • Naltrexone