Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp

Doralyn S Dalisay; Tadeusz F Molinski

doi:10.1021/ol9004189

Structure elucidation at the nanomole scale. 2. Hemi-phorboxazole A from Phorbas sp

Org Lett. 2009 May 7;11(9):1967-70. doi: 10.1021/ol9004189.

Authors

Doralyn S Dalisay¹, Tadeusz F Molinski

Affiliation

¹ Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

PMID: 19341267
DOI: 10.1021/ol9004189

Abstract

Hemi-phorboxazole A, a minor truncated analogue of phorboxazole A from the marine sponge Phorbas sp., was isolated in a total yield of 16.5 microg (28 nmol). The structure was elucidated by application of integrated nanomole-scale natural product techniques, including cryomicroprobe NMR, (1)H-coupled HSQC, and circular dichroism (CD).

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Animals
Heterocyclic Compounds, 4 or More Rings / chemical synthesis*
Heterocyclic Compounds, 4 or More Rings / chemistry*
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Oxazoles / chemical synthesis*
Oxazoles / chemistry*
Porifera / chemistry*

Substances

Heterocyclic Compounds, 4 or More Rings
Oxazoles
hemiphorboxazole A
phorboxazole A

Abstract

Publication types

MeSH terms

Substances

Grants and funding