Effect of silver diammine fluoride on incipient caries lesions in erupting permanent first molars: a pilot study

J Dent Child (Chic). Jan-Apr 2009;76(1):28-33.


Purpose: This study's purpose was to test silver diammine fluoride (SDF) in arresting incipient occlusal caries in erupting permanent first molars and to compare it with other approaches.

Methods: Sixty-six first erupting permanent molars were randomly divided into 3 groups: cross tooth-brushing technique (CTT), application of SDF, and glass ionomer fissure sealant (GIC). The clinical procedures were conducted by the same dentist. Teeth were assessed clinically by 1 blinded examiner using visual inspection at baseline and after 3, 6, 12, 18, and 30 months and radiographically at 6-, 12-, and 30-month follow-up evaluations. The Kruskall-Wallis test was used to compare noninvasive treatments, and the Friedman test was performed to evaluate differences for each group during different follow-up periods.

Results: A reduced number of active caries lesions was noted in all groups. After 3 and 6 months, SDF showed a significantly greater capacity for arresting caries lesions than CTT and GIC. At 18- and 30-month evaluations, no differences were observed among the 3 groups. All groups showed differences between baseline and all follow-up re-examinations.

Conclusions: All the tested techniques are equally efficient in controlling initial occlusal caries in erupting permanent first molars after 30-months of follow-up.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cariostatic Agents / therapeutic use*
  • DMF Index
  • Dental Caries / diagnostic imaging
  • Dental Caries / prevention & control*
  • Dentition, Permanent
  • Fluorides, Topical / therapeutic use*
  • Glass Ionomer Cements / pharmacology*
  • Humans
  • Molar* / diagnostic imaging
  • Pilot Projects
  • Quaternary Ammonium Compounds / therapeutic use*
  • Radiography
  • Random Allocation
  • Silver Compounds
  • Statistics, Nonparametric
  • Toothbrushing / methods*
  • Treatment Outcome


  • Cariostatic Agents
  • Fluorides, Topical
  • Glass Ionomer Cements
  • Quaternary Ammonium Compounds
  • Silver Compounds
  • silver diamine fluoride