Phospholipase D Signalling and Its Involvement in Neurite Outgrowth

Biochim Biophys Acta. 2009 Sep;1791(9):898-904. doi: 10.1016/j.bbalip.2009.03.010. Epub 2009 Mar 31.


Since the original discovery and structural elucidation of the mammalian phospholipase D (PLD), its potential to play a role in the lipid signalling pathway has attracted considerable interest. Now, it is generally accepted that different PLD isozymes are likely to serve diverse functions in membrane trafficking, endocytosis, exocytosis, cell growth, differentiation and actin cytoskeletal organization. In addition, PLDs are known to play a key role in neurite outgrowth, especially axon outgrowth, in neuronal cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biocatalysis
  • Humans
  • Isoenzymes / chemistry
  • Isoenzymes / metabolism
  • Neurites / enzymology*
  • Phospholipase D / chemistry
  • Phospholipase D / metabolism*
  • Signal Transduction*


  • Isoenzymes
  • Phospholipase D