Pharmacokinetics of [6]-gingerol after intravenous administration in rats

Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1612-4. doi: 10.1248/cpb.39.1612.

Abstract

A high-performance liquid chromatographic method to determine [6]-gingerol, a pungent constituent of ginger, in rat plasma was developed and a pharmacokinetic study was performed in rats. Quantitative analysis with high reproducibility was achieved for [6]-gingerol over the concentration range of 0.2-40 micrograms/ml. After bolus intravenous administration at a dose of 3 mg/kg, the plasma concentration-time curve was described by a two-compartment open model. [6]-Gingerol was rapidly cleared from plasma with a terminal half-life of 7.23 min and a total body clearance of 16.8 ml/min/kg. Serum protein binding of [6]-gingerol was 92.4%.

MeSH terms

  • Animals
  • Blood Proteins / metabolism
  • Catechols
  • Fatty Alcohols / administration & dosage
  • Fatty Alcohols / blood
  • Fatty Alcohols / pharmacokinetics*
  • Injections, Intravenous
  • Male
  • Protein Binding
  • Rats
  • Rats, Inbred Strains

Substances

  • Blood Proteins
  • Catechols
  • Fatty Alcohols
  • gingerol