Antigen presentation by dendritic cells in vivo

Curr Opin Immunol. 2009 Feb;21(1):105-10. doi: 10.1016/j.coi.2009.03.011. Epub 2009 Apr 1.


Dendritic cells (DC) are heterogenous, comprising several subpopulations of migratory and lymphoid-organ-resident types. Recent studies addressing the role of each subset in antigen presentation in vivo have revealed a complex division of labor within the DC network. In addition to CD8(+) DC, migratory lung or dermal DC can cross-present antigen in vivo. Migratory DC also transport to the lymph nodes antigens that can be transferred to resident DC for presentation. In inflammatory conditions, the antigen-presentation abilities of DC can be severely impaired, but an additional population of monocyte-derived DC then comes into play. Understanding the contribution of each DC subset to a physiological immune response is particularly relevant for rational vaccine design.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen Presentation*
  • Antigens, Bacterial / immunology
  • Antigens, Neoplasm / immunology
  • Antigens, Protozoan / immunology
  • Bacterial Infections / immunology*
  • Bacterial Infections / prevention & control
  • Cell Movement / immunology
  • Cross-Priming
  • Dendritic Cells / cytology
  • Dendritic Cells / immunology*
  • Dendritic Cells / metabolism
  • Humans
  • Malaria / immunology*
  • Malaria / prevention & control
  • Mice
  • Neoplasms / immunology*
  • Neoplasms / prevention & control
  • Plasmodium berghei / immunology
  • Vaccines / immunology


  • Antigens, Bacterial
  • Antigens, Neoplasm
  • Antigens, Protozoan
  • Vaccines