The role of radiation therapy in pancreatic cancer continues to be investigated. Its use in the adjuvant setting remains controversial. Its use is more generally accepted in borderline resectable disease, but prospective data are sparse. Randomized trials have yielded conflicting data in locally advanced disease. Radiation techniques have improved over time, such that findings in older trials are not necessarily applicable in modern practice. This article reviews the role of radiation in resectable, borderline resectable, and unresectable pancreatic cancer.