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Case Reports
. 2009 Aug;53(2):229-31.
doi: 10.1002/pbc.22026.

An Infant With Self-Healing Cutaneous Langerhans Cell Histiocytosis Followed by Isolated Thymic Relapse

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Case Reports

An Infant With Self-Healing Cutaneous Langerhans Cell Histiocytosis Followed by Isolated Thymic Relapse

Naoki Hatakeyama et al. Pediatr Blood Cancer. .

Abstract

Thymic involvement with Langerhans cell histiocytosis (LCH) typically occurs in children as part of multi-system (M-S) LCH. Patients who develop skin-only LCH during infancy may either follow a self-healing course with spontaneous regression or may progress to M-S involvement. We describe a male infant who developed isolated thymic LCH after spontaneous complete regression of isolated cutaneous lesions. His erythrocyte sedimentation rate and C-reactive protein increased temporarily during the skin-only stage of LCH, and increased again considerably during the thymic relapse. Even for patients with skin-only LCH, these laboratory data might indicate possible relapse or late progression of the disease.

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