A Nurr1 pathway for neuroprotection

Cell. 2009 Apr 3;137(1):26-8. doi: 10.1016/j.cell.2009.03.024.

Abstract

Mutations in the gene encoding the orphan nuclear receptor Nurr1 are linked to a rare familial form of Parkinson's disease. By examining the function of its mouse homolog, Saijo et al. (2009) provide evidence that Nurr1 protects dopaminergic neurons by suppressing inflammatory gene expression in astrocytes and microglia.

Publication types

  • Comment
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Astrocytes / metabolism
  • DNA-Binding Proteins / metabolism*
  • Mice
  • Microglia / metabolism
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Parkinson Disease / metabolism*
  • Signal Transduction
  • Transcription Factors / metabolism*

Substances

  • DNA-Binding Proteins
  • Nr4a2 protein, mouse
  • Nuclear Receptor Subfamily 4, Group A, Member 2
  • Transcription Factors