The vertebrate primary cilium in development, homeostasis, and disease

Cell. 2009 Apr 3;137(1):32-45. doi: 10.1016/j.cell.2009.03.023.


Cilia are complex structures that have garnered interest because of their roles in vertebrate development and their involvement in human genetic disorders. In contrast to multicellular invertebrates in which cilia are restricted to specific cell types, these organelles are found almost ubiquitously in vertebrate cells, where they serve a diverse set of signaling functions. Here, we highlight properties of vertebrate cilia, with particular emphasis on their relationship with other subcellular structures, and explore the physiological consequences of ciliary dysfunction.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cilia / physiology*
  • Eukaryota / cytology
  • Humans
  • Signal Transduction
  • Transcription, Genetic
  • Vertebrates / physiology*