Efficacy of an activated charcoal-simethicone combination in dyspeptic syndrome: results of a randomized prospective study in general practice

Gastroenterol Clin Biol. 2009 Jun-Jul;33(6-7):478-84. doi: 10.1016/j.gcb.2008.09.021. Epub 2009 Apr 5.

Abstract

Aim: The aim of this prospective, multicenter, randomized, placebo-controlled trial was to evaluate the efficacy of a commercial combination of simethicone and activated charcoal (Carbosylane) on dyspeptic symptoms in patients consulting a general practitioner.

Patients and methods: A total of 132 patients were studied. Treatment duration was 3 months, followed by a 2 months follow-up period.

Results: At the end of the treatment period, the percentage of patients with a reduction of at least two points on the symptom intensity scale was significantly higher with Carbosylane than with a placebo (P=0.043). Compared with placebo, the intensity of three symptoms (abdominal fullness, bloating and the sensation of slow digestion) was significantly decreased after 90 days of Carbosylane (P<0.05). At the end of the post-treatment follow-up, the percentages of patients with moderate or severe global complaints were 6.78% and 21.43% in the Carbosylane and placebo groups, respectively (P<0.03).

Conclusion: Among patients consulting a general practitioner for dyspeptic syndrome, 3 months of treatment with Carbosylane resulted in significant symptomatic improvement. The improvement was still evident 2 months after the end of treatment.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Antidotes / therapeutic use*
  • Charcoal / therapeutic use*
  • Double-Blind Method
  • Drug Combinations
  • Dyspepsia / drug therapy*
  • Family Practice
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Severity of Illness Index
  • Simethicone / therapeutic use*

Substances

  • Antidotes
  • Drug Combinations
  • Charcoal
  • Simethicone