Endothelial adapter proteins in leukocyte transmigration

Thromb Haemost. 2009 Apr;101(4):649-55.


Leukocyte transendothelial migration (TEM) requires endothelial signalling. This signalling is initiated by clustering of cell-surface adhesion molecules and transmitted into the endothelium by a group of associated or co-clustered adapter proteins. These adapter proteins, such as cortactin and filamin, connect the adhesion molecules to the actin cytoskeleton as well as to signalling enzymes and downstream pathways. This short review aims to define common themes in adapter protein binding in endothelial cells and to propose critical functions that are exerted by these adapters in leukocyte transendothelial migration.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Adhesion Molecules / metabolism*
  • Cytoskeleton / immunology
  • E-Selectin / metabolism
  • Endothelium, Vascular / immunology*
  • Humans
  • Intercellular Adhesion Molecule-1 / metabolism
  • Leukocyte Rolling*
  • Membrane Glycoproteins / metabolism
  • Signal Transduction*
  • Vascular Cell Adhesion Molecule-1 / metabolism


  • Cell Adhesion Molecules
  • E-Selectin
  • Membrane Glycoproteins
  • P-selectin ligand protein
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1