Relationships of PAI-1 levels to central obesity and liver steatosis in a sample of adult male population in southern Italy

Intern Emerg Med. 2009 Aug;4(4):315-23. doi: 10.1007/s11739-009-0240-9. Epub 2009 Apr 7.


To analyse the relationship of PAI-1 plasma levels to echographically determined liver steatosis and cardiometabolic risk factors in a randomly selected sample of 254 adult male participants of the Olivetti Heart Study. Accounting for age and ongoing pharmacological treatment, PAI-1 levels were directly (P < 0.005) associated with body mass index (BMI), waist circumference (WC), serum triglyceride (TG), total cholesterol, insulin, homeostasis model assessment index, gamma-glutamyl transpeptidase and peritoneal fat. At multiple linear regression (MLR) analysis, measures of adiposity and TG exerted significant and quantitatively similar effects on PAI-1 levels. A progressive rise in PAI-1 level was detected with increasing degree of steatosis. A stepwise MLR model was used to evaluate the relative power of cardiometabolic risk factors and liver steatosis on PAI-1 levels. Adjusting for alcohol intake, BMI, WC and peritoneal fat were alternatively included in the model with other variables found to be significantly associated with plasma PAI-1 level. Liver steatosis, serum TG and various indexes of adiposity each had a significant independent impact on PAI-1 plasma level and explained overall 23% of its variability. Abdominal fat, liver steatosis and serum TG levels were significant and independent determinants of PAI-1 plasma level in an unselected sample of adult male population upon adjustment for age and therapy.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / metabolism
  • Fatty Liver / blood*
  • Fatty Liver / diagnostic imaging
  • Humans
  • Italy
  • Male
  • Middle Aged
  • Obesity / blood*
  • Plasminogen Activator Inhibitor 1 / blood*
  • Surveys and Questionnaires
  • Ultrasonography


  • Plasminogen Activator Inhibitor 1
  • SERPINE1 protein, human