Adsorption, diffusion, and self-assembly of an engineered gold-binding peptide on Au(111) investigated by atomic force microscopy

Angew Chem Int Ed Engl. 2009;48(28):5174-7. doi: 10.1002/anie.200805259.


Go for the gold! The structural evolution of peptide binding and assembly on a Au(111) surface is dynamic and involves surface diffusion and multiple stages of molecular thin-film topology development (see schematic depiction and corresponding AFM images). The new fundamental observations may form the basis of peptide-based novel hybrid molecular technologies of the future.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adsorption
  • Amino Acid Sequence
  • Diffusion
  • Gold / chemistry*
  • Microscopy, Atomic Force
  • Peptides / chemistry*
  • Protein Binding
  • Protein Engineering


  • Peptides
  • Gold