Acute generalized exanthematous pustulosis: a rare clinical entity with use of piperacillin/tazobactam

Am J Ther. 2009 Nov-Dec;16(6):591-2. doi: 10.1097/MJT.0b013e31818d5f6d.


Acute generalized exanthematous pustulosis (AGEP) is a rare disorder characterized by an acute episode and sudden onset of erythematous and edematous eruptions of hundreds of sterile pustules. It is a self-limiting condition accompanied by fever and has a rapid course. It is mostly caused by drugs especially antibiotics. It is diagnosed by skin biopsy, which shows intracorneal pustules and neutrophilic infiltration in dermis and epidermis. We report a case of a patient who developed this rare skin condition with the use of piperacillin/tazobactam (Zosyn). This is only second case of AGEP reported in literature with the use of Zosyn.

Publication types

  • Case Reports

MeSH terms

  • Acute Generalized Exanthematous Pustulosis / chemically induced*
  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Cellulitis / drug therapy
  • Drug Combinations
  • Drug Eruptions / etiology*
  • Female
  • Humans
  • Penicillanic Acid / adverse effects
  • Penicillanic Acid / analogs & derivatives*
  • Penicillanic Acid / therapeutic use
  • Piperacillin / adverse effects*
  • Piperacillin / therapeutic use
  • Tazobactam


  • Anti-Bacterial Agents
  • Drug Combinations
  • Penicillanic Acid
  • Tazobactam
  • Piperacillin