De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy

Br J Cancer. 2009 May 5;100(9):1369-72. doi: 10.1038/sj.bjc.6605007. Epub 2009 Apr 7.

Abstract

Enhanced lipid biosynthesis is a characteristic feature of cancer. Deregulated lipogenesis plays an important role in tumour cell survival. These observations suggest that enzymes in the lipid synthesis pathway would be rational therapeutic targets for cancer. To this end, we review the enzymes in de novo fatty-acid synthesis and related pathways.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATP Citrate (pro-S)-Lyase / metabolism
  • Antineoplastic Agents / therapeutic use*
  • Coenzyme A Ligases / metabolism
  • Drug Design*
  • Fatty Acid Synthase, Type I / genetics
  • Fatty Acid Synthase, Type I / metabolism
  • Fatty Acids / biosynthesis*
  • Gene Expression Regulation, Enzymologic
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neoplasms / drug therapy*
  • Neoplasms / enzymology

Substances

  • Antineoplastic Agents
  • Fatty Acids
  • FASN protein, human
  • Fatty Acid Synthase, Type I
  • ATP Citrate (pro-S)-Lyase
  • Coenzyme A Ligases