Baseline characteristics of participants in the Hypertension in the Very Elderly Trial (HYVET)

Blood Press. 2009;18(1-2):17-22. doi: 10.1080/08037050902836779.


The Hypertension in the Very Elderly Trial (HYVET) is a randomized double-blind trial of active antihypertensive treatment (indapamide 1.5 mg sustained release +/-2-4 mg perindopril) vs placebo in participants over the age of 80 years with a systolic blood pressure (SBP) of 160-199 mmHg during a placebo run-in period plus a diastolic blood pressure (DBP) of<110 mmHg. The trial has completed with 3845 subjects randomized and we report the baseline characteristics. The participants were a healthy group. The numbers smoking, drinking alcohol and having previous cardiovascular events were low, and their hypertensive status was not usually associated with the metabolic syndrome; 1.0% of the whole group had a total cholesterol over 8.0 mmol/l, 1.1% a blood sugar over 11.1 mmol/l (irrespective of anti-diabetic treatment) and 1.7% a serum urate over 460 micromol/l (women) and 0.6% over 520 micromol/l (men). A serum creatinine over 150 micromol/l excluded participants from the trial. The gender differences and age comparisons were as expected but the women had higher average total and high-density-lipoprotein-cholesterol blood concentrations. Those with prior cardiovascular disease had an excess of the known cardiovascular risk factors. The baseline characteristics provide a basis for further understanding of the HYVET results, which have been published recently.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over / physiology*
  • Alcohol Drinking / epidemiology
  • Anthropometry
  • Blood Glucose / analysis
  • Cholesterol, HDL / blood
  • Comorbidity
  • Creatinine / blood
  • Female
  • Hematocrit
  • Hemoglobins / analysis
  • Humans
  • Hypertension / blood
  • Hypertension / drug therapy*
  • Hypertension / epidemiology
  • Indapamide / therapeutic use*
  • Lipids / blood
  • Male
  • Patient Selection*
  • Perindopril / therapeutic use*
  • Randomized Controlled Trials as Topic / statistics & numerical data*
  • Smoking / epidemiology
  • Urea / blood
  • Uric Acid / blood


  • Blood Glucose
  • Cholesterol, HDL
  • Hemoglobins
  • Lipids
  • Uric Acid
  • Urea
  • Creatinine
  • Indapamide
  • Perindopril