Effect of fenugreek fiber on satiety, blood glucose and insulin response and energy intake in obese subjects

Phytother Res. 2009 Nov;23(11):1543-8. doi: 10.1002/ptr.2795.


Eighteen healthy obese subjects participated in a single blind, randomized, crossover study of three test breakfasts, containing 0 g (control), 4 g or 8 g of isolated fenugreek fiber. Subjects recorded ratings of hunger, satiety, fullness and prospective food consumption using visual analog scales (VAS) every 30 min for 3.5 h. Postprandial blood glucose and insulin responses were measured. Energy intake from an ad libitum lunch buffet and for the remainder of the day was assessed. The 8 g dose of fenugreek fiber significantly increased mean ratings of satiety and fullness, and reduced ratings of hunger and prospective food consumption (P < 0.05). Palatability was significantly reduced with increasing doses of fenugreek fiber (P < 0.05). No differences were observed for area under the curve (AUC) for blood glucose among treatments. An increase in insulin AUC was found with 8 g fenugreek fiber. Energy intake at an ad libitum lunch buffet was significantly lower for 8 g than 4 g fenugreek fiber, but not significantly different from control, although there was a trend towards a lower intake (p = 0.11). No differences were observed for energy intake for the remainder of the day. Fenugreek fiber (8 g) significantly increased satiety and reduced energy intake at lunch, suggesting it may have short-term beneficial effects in obese subjects. Satiety results were not related to postprandial blood glucose.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Area Under Curve
  • Blood Glucose / drug effects*
  • Cross-Over Studies
  • Eating / drug effects
  • Eating / physiology
  • Energy Intake / drug effects*
  • Energy Intake / physiology
  • Female
  • Humans
  • Hunger / physiology
  • Insulin / blood*
  • Male
  • Middle Aged
  • Obesity
  • Plant Extracts / pharmacology*
  • Satiation / physiology
  • Single-Blind Method
  • Trigonella
  • Young Adult


  • Blood Glucose
  • Insulin
  • Plant Extracts
  • fenugreek seed meal