Abstract
Dynamic duo: Magnetic resonance imaging (MRI) can visualize deep regions of living bodies, whereas fluorescence measurement offers excellent sensitivity. These methods thus offer signal enhancement potential for detecting enzyme activities. A dual-mode off/on probe to detect caspase-3 activity by fluorescence and (19)F MRI is presented.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Caspase 3 / chemistry*
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Fluorescence
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Fluorine / chemistry*
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Luminescent Measurements
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Nuclear Magnetic Resonance, Biomolecular*
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Oligopeptides / chemical synthesis
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Oligopeptides / chemistry*
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Organometallic Compounds / chemical synthesis
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Organometallic Compounds / chemistry*
Substances
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Fluorescent Dyes
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Oligopeptides
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Organometallic Compounds
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gadolinum-DOTA-aspartyl-glutamyl-valyl-aspartic acid -7-amino-4-trifluoromethylcoumarin
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gadolinum-DOTA-aspartyl-glutamyl-valyl-aspartic acid 4-trifluoromethoxybenzylamide
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Fluorine
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Caspase 3