Levels of inflammatory markers and their correlation with dyslipidemia in diabetics

J Coll Physicians Surg Pak. 2009 Apr;19(4):207-10.

Abstract

Objective: To measure the levels of inflammatory markers (serum ferritin and high sensitivity C-reactive protein) and dyslipidemia in diabetics and to find a correlation between these inflammatory markers and dyslipidemia.

Study design: Comparative study.

Place and duration of study: Department of Biochemistry and Molecular Biology, Army Medical College, Rawalpindi, from March 2007 to February 2008.

Methodology: The study included 30 known type-2 diabetic patients randomly inducted from diabetic clinics of Rawalpindi. Healthy volunteers (n=30) having blood glucose less than 6 mmol/L were inducted as the comparison group. Fasting blood samples of diabetics and controls were analyzed for glucose, glycated hemoglobin (HbA1c), lipid profile, high sensitivity C-reactive protein (hs-CRP) and serum ferritin.

Results: The diabetic subjects had significantly higher levels of glucose, HbA1c, total cholesterol, LDL cholesterol, triglycerides, hs-CRP and ferritin as compared to normal subjects (p<0.001), while the level of HDL cholesterol was significantly lower in diabetics (p<0.001). Furthermore, a significant positive correlation was found between the inflammatory markers, hs-CRP and ferritin, and the parameters of dyslipidemia i.e. total cholesterol, LDL cholesterol and triglycerides (p<0.001 r=0.72) except for HDL cholesterol, which had an insignificant negative correlation with the inflammatory markers (p>0.05 r=-0.10).

Conclusion: Low-grade inflammation exists in Diabetes mellitus and it is positively related with dyslipidemia (except for HDL cholesterol) in diabetics.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biomarkers / blood*
  • Blood Glucose / analysis
  • C-Reactive Protein / analysis
  • Case-Control Studies
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / pathology
  • Dyslipidemias / blood
  • Dyslipidemias / complications*
  • Dyslipidemias / diagnosis
  • Female
  • Ferritins / blood
  • Glycated Hemoglobin A / analysis
  • Humans
  • Inflammation / blood
  • Inflammation / complications*
  • Inflammation / pathology
  • Male
  • Middle Aged
  • Statistics as Topic
  • Triglycerides / blood
  • Young Adult

Substances

  • Biomarkers
  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Glycated Hemoglobin A
  • Triglycerides
  • C-Reactive Protein
  • Ferritins