Fluorescence image-guided surgery and repetitive Photodynamic Therapy in brain metastatic malignant melanoma

Photodiagnosis Photodyn Ther. 2008 Dec;5(4):264-6. doi: 10.1016/j.pdpdt.2009.01.001. Epub 2009 Feb 7.


Metastatic brain melanoma occurs in about 3.5% of patients suffering from malignant melanoma. It has disabling effects on cognition, memory, language and mobility. We studied the use of fluorescence image-guided resection and repetitive Photodynamic Therapy in six consecutive metastatic brain melanomas. Three were males and the mean age of the group was 52.8 years.

Results: All six patients (100%) remained free of brain disease till death, 50% died of malignant melanoma elsewhere, and 50% died of unrelated causes.

Conclusion: Adjuvant fluorescence image-guided resection and repetitive Photodynamic Therapy offers an excellent local control of metastatic brain melanoma.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged, 80 and over
  • Brain Neoplasms / pathology
  • Brain Neoplasms / secondary*
  • Brain Neoplasms / therapy*
  • Dihematoporphyrin Ether / therapeutic use*
  • Female
  • Humans
  • Male
  • Melanoma / pathology
  • Melanoma / secondary*
  • Melanoma / therapy*
  • Middle Aged
  • Photochemotherapy / methods*
  • Photosensitizing Agents / therapeutic use
  • Surgery, Computer-Assisted / methods*
  • Treatment Outcome


  • Photosensitizing Agents
  • Dihematoporphyrin Ether