Bisphosphonates and osteonecrosis: potential treatment or serious complication?

Orthop Clin North Am. 2009 Apr;40(2):223-34. doi: 10.1016/j.ocl.2008.12.002.

Abstract

They are commonly used to treat osteoporosis and other diseases that involve osteoclast-mediated bone resorption, including Paget's disease and multiple myeloma. Their use in treating osteonecrosis of the femoral head has been studied and theoretically holds promise. There are complications associated with these medications, however, including the development of osteonecrosis in the jaw.

Publication types

  • Review

MeSH terms

  • Bone Density Conservation Agents / adverse effects*
  • Bone Density Conservation Agents / therapeutic use
  • Bone Resorption / metabolism
  • Bone Resorption / pathology
  • Bone Resorption / prevention & control
  • Bone and Bones / chemistry
  • Bone and Bones / drug effects
  • Diphosphonates / adverse effects*
  • Diphosphonates / pharmacokinetics
  • Diphosphonates / therapeutic use
  • Humans
  • Osteonecrosis / chemically induced*
  • Osteonecrosis / metabolism
  • Osteonecrosis / pathology
  • Risk Factors

Substances

  • Bone Density Conservation Agents
  • Diphosphonates