Hyperexcitability, persistent Na+ conductances and neurodegeneration in amyotrophic lateral sclerosis

Exp Neurol. 2009 Jul;218(1):1-4. doi: 10.1016/j.expneurol.2009.03.039. Epub 2009 Apr 8.

Author

Matthew C Kiernan¹

Affiliation

¹ Prince of Wales Medical Research Institute and Prince of Wales Clinical School, University of New South Wales, Barker Street, Randwick, Sydney, NSW 2031, Australia. M.kiernan@unsw.edu.au

PMID: 19361500
DOI: 10.1016/j.expneurol.2009.03.039

No abstract available

Publication types

Comment

MeSH terms

Amyotrophic Lateral Sclerosis / complications*
Amyotrophic Lateral Sclerosis / genetics
Amyotrophic Lateral Sclerosis / pathology
Animals
Biophysical Phenomena / drug effects
Biophysical Phenomena / genetics
Cerebral Cortex / pathology
Glutamic Acid / toxicity
Humans
Nerve Degeneration / etiology*
Nerve Degeneration / genetics
Neural Conduction / drug effects
Neural Conduction / physiology*
Sodium Channels / drug effects
Sodium Channels / physiology*

Substances

Sodium Channels
Glutamic Acid