Bacterial Fatty Acid Synthesis and Its Relationships With Polyketide Synthetic Pathways

Methods Enzymol. 2009;459:395-433. doi: 10.1016/S0076-6879(09)04617-5.


This review presents the most thoroughly studied bacterial fatty acid synthetic pathway, that of Escherichia coli and then discusses the exceptions to the E. coli pathway present in other bacteria. The known interrelationships between the fatty acid and polyketide synthetic pathways are also assessed, mainly in the Streptomyces group of bacteria. Finally, we present a compendium of methods for analysis of bacterial fatty acid synthetic pathways.

MeSH terms

  • Bacteria / genetics
  • Bacteria / metabolism*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / metabolism
  • Fatty Acids / biosynthesis*
  • Macrolides / metabolism*
  • Models, Biological
  • Signal Transduction / genetics
  • Signal Transduction / physiology


  • Bacterial Proteins
  • Fatty Acids
  • Macrolides