Abstract
Three monoterpene-chalcone conjugates, including two novel compounds isorubraine (2) and sumadain C (3), and a known compound rubraine (1) were isolated from the seeds of Alpinia katsumadai. Their structures and relative configurations were established by NMR spectroscopy and X-ray crystallography. Cytotoxic activities of these compounds were evaluated against cell lines HepG2, MCF-7 and MAD-MB-435, and compound 3 exhibited potent cytotoxic activity.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alpinia / chemistry*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / toxicity*
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Cell Line, Tumor
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Chalcone / chemistry*
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Chalcones / chemistry
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Chalcones / isolation & purification
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Chalcones / toxicity*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Molecular Conformation
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Monoterpenes / chemistry*
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Monoterpenes / isolation & purification
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Monoterpenes / toxicity
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Plants, Medicinal / chemistry
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Seeds / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Chalcones
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Monoterpenes
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isorubraine
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sumadain C
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Chalcone