Two novel monoterpene-chalcone conjugates isolated from the seeds of Alpinia katsumadai

Bioorg Med Chem Lett. 2009 May 15;19(10):2728-30. doi: 10.1016/j.bmcl.2009.03.117. Epub 2009 Mar 28.

Abstract

Three monoterpene-chalcone conjugates, including two novel compounds isorubraine (2) and sumadain C (3), and a known compound rubraine (1) were isolated from the seeds of Alpinia katsumadai. Their structures and relative configurations were established by NMR spectroscopy and X-ray crystallography. Cytotoxic activities of these compounds were evaluated against cell lines HepG2, MCF-7 and MAD-MB-435, and compound 3 exhibited potent cytotoxic activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alpinia / chemistry*
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / toxicity*
  • Cell Line, Tumor
  • Chalcone / chemistry*
  • Chalcones / chemistry
  • Chalcones / isolation & purification
  • Chalcones / toxicity*
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Humans
  • Molecular Conformation
  • Monoterpenes / chemistry*
  • Monoterpenes / isolation & purification
  • Monoterpenes / toxicity
  • Plants, Medicinal / chemistry
  • Seeds / chemistry

Substances

  • Antineoplastic Agents, Phytogenic
  • Chalcones
  • Monoterpenes
  • isorubraine
  • sumadain C
  • Chalcone