The WAVE regulatory complex is inhibited

Nat Struct Mol Biol. 2009 May;16(5):561-3. doi: 10.1038/nsmb.1587. Epub 2009 Apr 12.


The WAVE regulatory complex (WRC) transmits information from the Rac GTPase to the actin nucleator Arp2/3 complex. We have reconstituted recombinant human and Drosophila WRC in several forms and shown that they are inactive toward Arp2/3 complex but can be activated by Rac in a nucleotide-dependent fashion. Our observations identify core components needed for WAVE inhibition, reconcile contradictory existing mechanisms and reveal common regulatory principles for the WAVE/WASP family of proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila melanogaster / metabolism
  • Electrophoresis, Polyacrylamide Gel
  • Humans
  • Recombinant Proteins / metabolism
  • Wiskott-Aldrich Syndrome Protein Family / antagonists & inhibitors*


  • Recombinant Proteins
  • Wiskott-Aldrich Syndrome Protein Family