Comparative efficacies of telavancin and vancomycin in preventing device-associated colonization and infection by Staphylococcus aureus in rabbits

Antimicrob Agents Chemother. 2009 Jun;53(6):2626-8. doi: 10.1128/AAC.01101-08. Epub 2009 Apr 13.


Telavancin is an investigational lipoglycopeptide antibiotic that is active against gram-positive pathogens. In an in vivo rabbit model, subtherapeutic (15-mg/kg) and therapeutic (30- or 45-mg/kg) doses of telavancin were demonstrated to be noninferior and superior to vancomycin (20 mg/kg), respectively, for preventing subcutaneous implant colonization and infection by Staphylococcus aureus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aminoglycosides / therapeutic use*
  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Catheter-Related Infections / prevention & control*
  • Female
  • Lipoglycopeptides
  • Rabbits
  • Staphylococcal Infections / prevention & control*
  • Vancomycin / therapeutic use*


  • Aminoglycosides
  • Anti-Bacterial Agents
  • Lipoglycopeptides
  • Vancomycin
  • telavancin