Multiple target regulation by small noncoding RNAs rewires gene expression at the post-transcriptional level

Res Microbiol. 2009 May;160(4):278-87. doi: 10.1016/j.resmic.2009.03.004. Epub 2009 Apr 12.


Small noncoding RNAs (sRNAs), often in conjunction with Hfq protein, have increasingly been shown to regulate multiple rather than individual mRNAs, thereby reprogramming gene expression at the post-transcriptional level. This review summarizes how and when several such regulators (CyaR, DsrA, GcvB, OmrAB, RNAIII, RybB, RyhB) act upon multiple targets.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacteria / metabolism
  • Escherichia coli Proteins / metabolism
  • Gene Expression Regulation, Bacterial*
  • Host Factor 1 Protein / metabolism
  • RNA Processing, Post-Transcriptional*
  • RNA, Bacterial / physiology
  • RNA, Messenger / metabolism
  • RNA, Untranslated / physiology*
  • Stress, Physiological / genetics


  • Escherichia coli Proteins
  • Hfq protein, E coli
  • Host Factor 1 Protein
  • RNA, Bacterial
  • RNA, Messenger
  • RNA, Untranslated