[Giant cell tumors of soft tissue arising in surgical scars]

Pathologe. 2009 Sep;30(5):401-6. doi: 10.1007/s00292-009-1142-3.
[Article in German]

Abstract

Giant cell tumor of soft tissue (GCT-ST) is a rare primary soft tissue tumor with low malignant potential. It is clinically and pathologically similar to the giant cell tumor of the bone. Two cases of GCT-ST in surgical scars are reported. Both tumors were initially regarded as tumor relapses of a leiomyosarcoma of deep soft tissue and a dermal in situ squamous cell carcinoma, respectively. The development of GCT-ST in surgical scars has not been observed previously. These findings suggest chronic inflammation and tissue repair as etiological factors in the development of GCT-ST. The period of time between initial surgical intervention and the development of the GCT-ST seems to be unusually short for the development of a "true" second neoplasm, which may underline the sometimes diffuse border between reactive "pseudosarcomatous" and neoplastic fibro-histiocytic lesions.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Aged
  • Carcinoma in Situ / pathology
  • Carcinoma in Situ / surgery
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / surgery
  • Cicatrix / pathology*
  • Diagnosis, Differential
  • Facial Neoplasms / pathology
  • Facial Neoplasms / surgery
  • Giant Cell Tumors / pathology*
  • Giant Cell Tumors / surgery
  • Groin / pathology
  • Groin / surgery
  • Humans
  • Leiomyosarcoma / pathology
  • Leiomyosarcoma / surgery
  • Male
  • Neoplasm Recurrence, Local / pathology
  • Neoplasm Recurrence, Local / surgery
  • Neoplasms, Second Primary / pathology*
  • Neoplasms, Second Primary / surgery
  • Parotid Neoplasms / pathology
  • Parotid Neoplasms / secondary
  • Postoperative Complications / pathology*
  • Postoperative Complications / surgery
  • Reoperation
  • Saphenous Vein / pathology
  • Saphenous Vein / surgery
  • Skin Neoplasms / pathology
  • Skin Neoplasms / surgery
  • Soft Tissue Neoplasms / pathology*
  • Soft Tissue Neoplasms / surgery
  • Vascular Neoplasms / pathology
  • Vascular Neoplasms / surgery
  • Venous Thrombosis / pathology
  • Venous Thrombosis / surgery