A study on clinical and biochemical profile of low body weight type 2 diabetes mellitus

J Indian Med Assoc. 2008 Nov;106(11):747-50.


Low body weight type2 diabetes mellitus (T2DM) is a distinct entity in T2DM having different clinical presentation, morbidity and mortality patterns as well as biochemical profile when compared with classical T2 DM. This study was aimed at comparing three subtypes of T2 DM-overweight (BMI>25), normal weight (BMI>18.5 but <25) and low body weight or lean type2 DM (BM1<18.5). Seventy-five cases of T2 DM (25-lean, 25-normal weight and 25-overweight) were selected. The present study revealed that normal C-peptide level with basal hyperglycaemia is an important characteristic of lean T2 DM. Lower prevalence of hypercholesterolaemia and higher level of triglycerides were found in low body weight T2 DM.Lower prevalence of macrovascular and higher prevalence of microvascular complications are also noted.

MeSH terms

  • Adult
  • Blood Glucose / metabolism
  • Body Mass Index*
  • Body Weight*
  • C-Peptide / blood
  • Cholesterol / blood
  • Comorbidity
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / classification*
  • Diabetes Mellitus, Type 2 / diagnosis*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetic Angiopathies / epidemiology
  • Female
  • Glycated Hemoglobin A / metabolism
  • Humans
  • India / epidemiology
  • Male
  • Middle Aged
  • Triglycerides / blood


  • Blood Glucose
  • C-Peptide
  • Glycated Hemoglobin A
  • Triglycerides
  • Cholesterol