The companions: regulatory T cells and gene therapy

Immunology. 2009 May;127(1):1-7. doi: 10.1111/j.1365-2567.2009.03069.x.


Undesired immunological responses to products of therapeutic gene replacement have been obstacles to successful gene therapy. Understanding such responses of the host immune system to achieve immunological tolerance to a transferred gene product is therefore crucial. In this article, we review relevant studies of immunological responses to gene replacement therapy, the role of immunological tolerance mediated by regulatory T cells in down-regulating the unwanted immune responses, and the interrelationship of the two topics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Genetic Therapy*
  • Humans
  • Immune Tolerance / genetics
  • Immune Tolerance / immunology
  • Male
  • Muscular Dystrophy, Duchenne / immunology
  • Muscular Dystrophy, Duchenne / therapy
  • T-Lymphocytes, Regulatory / immunology*