LS-SNP/PDB: annotated non-synonymous SNPs mapped to Protein Data Bank structures

Bioinformatics. 2009 Jun 1;25(11):1431-2. doi: 10.1093/bioinformatics/btp242. Epub 2009 Apr 15.


Summary: LS-SNP/PDB is a new WWW resource for genome-wide annotation of human non-synonymous (amino acid changing) SNPs. It serves high-quality protein graphics rendered with UCSF Chimera molecular visualization software. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features.

Availability: LS-SNP/PDB is available at ( and via links from protein data bank (PDB) biology and chemistry tabs, UCSC Genome Browser Gene Details and SNP Details pages and PharmGKB Gene Variants Downloads/Cross-References pages.

MeSH terms

  • Computational Biology / methods*
  • Databases, Genetic
  • Databases, Protein* / standards
  • Humans
  • Internet
  • Polymorphism, Single Nucleotide*
  • Proteins / chemistry*
  • Sequence Analysis, Protein
  • Software*
  • User-Computer Interface


  • Proteins