Two Cases of Failed Ceftriaxone Treatment in Pharyngeal Gonorrhoea Verified by Molecular Microbiological Methods

J Med Microbiol. 2009 May;58(Pt 5):683-687. doi: 10.1099/jmm.0.007641-0.

Abstract

Diagnostic, genotypic and antibiotic-resistance determinants of Neisseria gonorrhoeae were analysed by molecular methods to verify the failure of ceftriaxone treatment in two cases of pharyngeal gonorrhoea. Monoplex assays were needed to define competitive inhibition of a positive Chlamydia PCR in a duplex assay. Different penA changes were detected in the N. gonorrhoeae isolated from the two cases. These were associated with raised ceftriaxone MICs of 0.03 and 0.016 mg l(-1), which may have contributed to the treatment failures in these cases.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Bacterial Agents / therapeutic use
  • Ceftriaxone / therapeutic use*
  • Chlamydia trachomatis / genetics
  • Chlamydia trachomatis / isolation & purification*
  • Female
  • Gonorrhea / drug therapy*
  • Homosexuality
  • Humans
  • Male
  • Neisseria gonorrhoeae / isolation & purification*
  • Pharyngeal Diseases / drug therapy*
  • Pharyngeal Diseases / microbiology*
  • Polymerase Chain Reaction
  • Treatment Failure

Substances

  • Anti-Bacterial Agents
  • Ceftriaxone