Fighting the flu with inflammasome signaling

David M Owen; Michael Gale Jr

doi:10.1016/j.immuni.2009.03.011

Fighting the flu with inflammasome signaling

Immunity. 2009 Apr 17;30(4):476-8. doi: 10.1016/j.immuni.2009.03.011.

Authors

David M Owen¹, Michael Gale Jr

Affiliation

¹ Department of Immunology, University of Washington, Seattle, WA 98195, USA.

PMID: 19371712
DOI: 10.1016/j.immuni.2009.03.011

Abstract

A wide variety of stimuli induce the inflammasome, but little is known about its role in immune protection against viruses. In this issue of Immunity, Allen et al. (2009) and Thomas et al. (2009) describe a critical role for NLRP3 induction of the inflammasome and protection against influenza virus infection.

Publication types

Comment

MeSH terms

Animals
Carrier Proteins / genetics
Carrier Proteins / immunology*
Humans
Influenza A virus / immunology*
Monocytes / immunology
NLR Family, Pyrin Domain-Containing 3 Protein
Neutrophils / immunology
Signal Transduction*

Substances

Carrier Proteins
NLR Family, Pyrin Domain-Containing 3 Protein
NLRP3 protein, human