The Conditional Ancestral Selection Graph With Strong Balancing Selection

Theor Popul Biol. 2009 Jun;75(4):355-64. doi: 10.1016/j.tpb.2009.04.002. Epub 2009 Apr 14.

Abstract

Using a heuristic separation-of-time-scales argument, we describe the behavior of the conditional ancestral selection graph with very strong balancing selection between a pair of alleles. In the limit as the strength of selection tends to infinity, we find that the ancestral process converges to a neutral structured coalescent, with two subpopulations representing the two alleles and mutation playing the role of migration. This agrees with a previous result of Kaplan et al., obtained using a different approach. We present the results of computer simulations to support our heuristic mathematical results. We also present a more rigorous demonstration that the neutral conditional ancestral process converges to the Kingman coalescent in the limit as the mutation rate tends to infinity.

MeSH terms

  • Alleles
  • Computer Simulation
  • Models, Theoretical
  • Selection, Genetic*