IL-17 and Th17 cells in human inflammatory diseases

Microbes Infect. 2009 Apr;11(5):625-30. doi: 10.1016/j.micinf.2009.04.003. Epub 2009 Apr 14.


IL-17 was discovered in 1995/96 as a T cell derived cytokine with effects on inflammation and neutrophil activation. In 2006, the precise cell source of IL-17 was identified in the mouse, and these cells were named Th17 cells. They play a role in various human diseases associated with inflammation and destruction such as rheumatoid arthritis, psoriasis, Crohn's disease, multiple sclerosis, where IL-17 can be seen as a therapeutic target.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / immunology*
  • Inflammation / pathology*
  • Interleukin-1 / immunology
  • Interleukin-17 / immunology*
  • Interleukin-17 / metabolism
  • Mice
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • Tumor Necrosis Factor-alpha / immunology


  • Interleukin-1
  • Interleukin-17
  • Tumor Necrosis Factor-alpha