Differentiation and function of pro-inflammatory Th17 cells

Microbes Infect. 2009 Apr;11(5):584-8. doi: 10.1016/j.micinf.2009.04.001. Epub 2009 Apr 14.


After activation, CD4+ helper T (Th) cells differentiate into cytokine-secreting effector subsets. A novel subset of CD4+ helper T (Th) cells that produce two related cytokines IL-17 and IL-17F has been recently identified and shown to play critical function in inflammation and autoimmunity. Here I summarize recent work by us as well as other investigators in understanding the transcriptional regulation of Th17-cell differentiation, their developmental relationship with regulatory T cells and the function of IL-17 and IL-17F in vivo.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation*
  • Gene Expression Regulation, Developmental
  • Inflammation / immunology*
  • Interleukin-17 / metabolism
  • T-Lymphocyte Subsets / cytology*
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocytes, Helper-Inducer / cytology*
  • T-Lymphocytes, Helper-Inducer / immunology*


  • Interleukin-17