Serum and dietary magnesium and risk of ischemic stroke: the Atherosclerosis Risk in Communities Study

Am J Epidemiol. 2009 Jun 15;169(12):1437-44. doi: 10.1093/aje/kwp071. Epub 2009 Apr 16.


The authors sought to examine the relation between serum or dietary magnesium and the incidence of ischemic stroke among blacks and whites. Between 1987 and 1989, 14,221 men and women aged 45-64 years took part in the first examination of the Atherosclerosis Risk in Communities Study cohort. The incidence of stroke was ascertained from hospital records. Higher serum magnesium levels were associated with lower prevalence of hypertension and diabetes mellitus at baseline. During the 15-year follow-up, 577 ischemic strokes occurred. Serum magnesium was inversely associated with ischemic stroke incidence. The age-, sex-, and race-adjusted rate ratios of ischemic stroke for those with serum magnesium levels of <or=1.5, 1.6, 1.7, and >or=1.8 mEq/L were 1.0, 0.78 (95% confidence interval (CI): 0.62, 0.96), 0.70 (95% CI: 0.56, 0.88), and 0.75 (95% CI: 0.59, 0.95) (P(trend) = 0.005). After adjustment for hypertension and diabetes, the rate ratios were attenuated to nonsignificant levels. Dietary magnesium intake was marginally inversely associated with the incidence of ischemic stroke (P(trend) = 0.09). Low serum magnesium levels could be associated with increased risk of ischemic stroke, in part, via effects on hypertension and diabetes.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Confidence Intervals
  • Diet
  • Female
  • Humans
  • Intracranial Arteriosclerosis / blood
  • Intracranial Arteriosclerosis / epidemiology*
  • Intracranial Arteriosclerosis / physiopathology
  • Magnesium Compounds / administration & dosage*
  • Magnesium Compounds / blood*
  • Male
  • Middle Aged
  • Nutrition Surveys
  • Nutritional Status*
  • Odds Ratio
  • Prospective Studies
  • Risk Factors
  • Stroke / blood
  • Stroke / epidemiology*
  • Stroke / physiopathology
  • Surveys and Questionnaires
  • United States


  • Magnesium Compounds