Bringing up the rear: defining the roles of the uropod

Nat Rev Mol Cell Biol. 2009 May;10(5):353-9. doi: 10.1038/nrm2680. Epub 2009 Apr 17.


Renewed interest in cell shape has been prompted by a recent flood of evidence that indicates that cell polarity is essential for the biology of motile cells. The uropod, a protrusion at the rear of amoeboid motile cells such as leukocytes, exemplifies the importance of morphology in cell motility. Remodelling of cell shape by uropod-interfering agents disturbs cell migration. But even though the mechanisms by which uropods regulate cell migration are beginning to emerge, their functional significance remains enigmatic.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement / genetics
  • Cell Movement / physiology
  • Cell Polarity / genetics
  • Cell Polarity / physiology*
  • Cell Shape / genetics
  • Cell Shape / physiology*
  • Eukaryota / cytology