Molecular modelling study of the 3D structure of the bovine viral diarrhea virus (BVDV) helicase

In Silico Biol. 2008;8(5-6):461-9.


Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.

MeSH terms

  • Adenosine Triphosphate / chemistry
  • Adenosine Triphosphate / metabolism
  • Amino Acid Sequence
  • Computer Simulation
  • Conserved Sequence
  • Diarrhea Viruses, Bovine Viral / enzymology*
  • Hepacivirus / enzymology
  • Imaging, Three-Dimensional
  • Models, Molecular
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • RNA Helicases / chemistry*
  • RNA Helicases / metabolism
  • RNA, Viral / chemistry
  • RNA, Viral / metabolism
  • Sequence Alignment
  • Static Electricity
  • Structural Homology, Protein
  • Substrate Specificity


  • RNA, Viral
  • Adenosine Triphosphate
  • RNA Helicases