Abstract
Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family of viruses and constitutes a very important pathogen for livestock around the world. The viral helicase is an enzyme essential for the proliferation and transmission of the virus. In this work a 3D-model of the BVDV helicase was produced using homology modelling techniques and the known 3D-structure of the hepatitis C helicase of the Flaviviridae family as template, in an attempt to provide the means for structure-based design of novel anti-BVDV agents.
MeSH terms
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Adenosine Triphosphate / chemistry
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Adenosine Triphosphate / metabolism
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Amino Acid Sequence
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Computer Simulation
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Conserved Sequence
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Diarrhea Viruses, Bovine Viral / enzymology*
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Hepacivirus / enzymology
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Imaging, Three-Dimensional
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Models, Molecular
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Molecular Sequence Data
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Protein Structure, Tertiary
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RNA Helicases / chemistry*
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RNA Helicases / metabolism
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RNA, Viral / chemistry
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RNA, Viral / metabolism
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Sequence Alignment
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Static Electricity
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Structural Homology, Protein
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Substrate Specificity
Substances
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RNA, Viral
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Adenosine Triphosphate
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RNA Helicases