Hereditary disorders in Saguenay-Lac-St-Jean (Quebec, Canada)

Hum Hered. 1991;41(3):141-6. doi: 10.1159/000153992.


Saguenay-Lac-St-Jean is a geographically isolated region located in northeastern Quebec. Opened to the white settlement in 1938, its immigrants mainly came from Charlevoix, another isolated region of Quebec. The prevalence and/or incidence of several autosomal dominant and recessive disorders are very high. The overall birth prevalence of the recessive disorders was calculated at 1/207 living births and the overall carrier rate at 1/7 inhabitants. This situation may be explained by migration and social factors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genes, Dominant
  • Genes, Recessive
  • Genetic Diseases, Inborn / epidemiology*
  • Genetics, Population
  • Humans
  • Incidence
  • Prevalence
  • Quebec / epidemiology
  • Rural Health