Gas injection versus vitrectomy with gas for treating retinal detachment owing to macular hole in high myopes

Ophthalmology. 2009 Jun;116(6):1182-87.e1. doi: 10.1016/j.ophtha.2009.01.003. Epub 2009 Apr 17.


Objective: To compare the efficacy between intravitreal gas injection alone and pars plana vitrectomy (PPV) with intraocular gas tamponade in treating retinal detachment due to macular hole in high myopes.

Design: Prospective, randomized controlled, multicenter study.

Participants: We included 231 eyes of 231 patients with retinal detachment owing to myopic macular hole from 14 study sites in China.

Intervention: The patients were randomly assigned to undergo intravitreal perfluoropropane (C3F8) gas injection (group A) or vitrectomy with intraocular C3F8 gas tamponade (group B).

Main outcome measures: Complete ocular examination included best-corrected visual acuity, applanation tonometry, slit-lamp biomicroscopy, color fundus photography, ultrasound examination, and optical coherence tomography at baseline and every 3 months after the surgery.

Results: At 12 months after surgery, the retinal reattachment rates was 59.8% (52 eyes) in group A, which was significantly lower than group B (79 eyes, 74.5%; P = 0.029). Logistic regression showed that PPV (P<0.001) and low height of retinal detachment at baseline (P = 0.068) were associated with a greater retinal reattachment rate. Subgroup analysis revealed that in group B, concomitant internal limiting membrane (ILM) peeling showed a slightly higher anatomic success rate (79.2%) than no ILM peeling (70.0%). The postoperative best-corrected visual acuity of the eyes with attached retina between group A and B was not significantly different (P>0.05).

Conclusions: Pars plana vitrectomy with C3F8 endotamponade resulted in a higher anatomic success rate than intravitreal C3F8 gas injection alone in treating retinal detachment owing to macular hole in high myopes.

Financial disclosure(s): The authors have no proprietary or commercial interest in any materials discussed in the article.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Combined Modality Therapy
  • Female
  • Fluorocarbons / administration & dosage*
  • Follow-Up Studies
  • Humans
  • Injections
  • Male
  • Middle Aged
  • Myopia, Degenerative / complications*
  • Prospective Studies
  • Retinal Detachment / etiology
  • Retinal Detachment / physiopathology
  • Retinal Detachment / surgery*
  • Retinal Perforations / etiology
  • Retinal Perforations / physiopathology
  • Retinal Perforations / surgery*
  • Tomography, Optical Coherence
  • Tonometry, Ocular
  • Visual Acuity / physiology
  • Vitrectomy / methods*
  • Young Adult


  • Fluorocarbons
  • perflutren